229E – Communicable Diseases Research

Human seasonal coronavirus neutralization and COVID-19 severity

인간 계절 코로나 바이러스 중화 및 COVID-19 심각성

Article

Published on 2022-10-012022-09-12
Journal: Journal of medical virology
[Category] COVID19(2023년), MERS, SARS, 진단,

Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Article

Published on 2022-09-272022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단, 치료기술,

[키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women
[DOI] 10.3389/fimmu.2022.999136 PMC 바로가기

Clinical significance and role of coinfections with respiratory pathogens among individuals with confirmed severe acute respiratory syndrome coronavirus-2 infection

Article

Published on 2022-09-022022-11-15
Journal: Frontiers in Public Health
[Category] SARS, 치료기술,

[키워드] 229E acute respiratory syndrome Adenovirus AdV age analyzed average C-reactive protein (CRP cause children Clinical data clinical feature clinical picture Clinical significance Coinfection collected Combination complications Coronavirus-2 COVID-19 CRP detect determine Diseases distribution highest HKU1 Hospital stay hospitalized patient individual Infection Influenza influenza A Influenza virus involved lymphocyte métapneumovirus NL63 OC43 other respiratory virus outcome Outpatient parainfluenza virus Patient patients with SARS Prevalence Prevent proportion respiratory pathogen respiratory syncytial virus respiratory virus respiratory viruses rhinovirus RSV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 positive patient Screening seasonal coronavirus specimen tested the disease the mean Treatment Viral load Viral load. virus was determined was used worsening
[DOI] 10.3389/fpubh.2022.959319 PMC 바로가기

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease

Article

Published on 2022-08-302022-11-16
Journal: mBio
[Category] SARS, 변종, 치료기술,

[키워드] 229E Activation acute respiratory syndrome affected airway being benefit Calu-3 cell change changes in cleavage conserved coronavirus creating Critical Delta dibasic experiment favor functional fusion peptide had no help host cell human coronavirus 229E humans immune evasion immunogenic Impact influence less MERS-CoV Middle East motif mutant Mutation mutations new SARS-CoV-2 no difference omicron pathogenic protease Proteases Protein pseudovirus pseudovirus entry reduced remained residue residues respiratory syndrome coronavirus reverse effect SARS-CoV-2 SARS-CoV-2 spike sequence shown spike spike functioning Spike protein spike protein. Surveillance the SARS-CoV-2 TMPRSS13 TMPRSS13 protease TMPRSS2 Tolerance variant variants Variation virus entry Wuhan-Hu-1
[DOI] 10.1128/mbio.01376-22 PMC 바로가기

Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Boosts Neutralizing Activity Against Seasonal Human Coronaviruses

중증 급성 호흡기 증후군 코로나바이러스 2 백신 접종은 계절성 인간 코로나바이러스에 대한 중화 활성을 향상시킵니다

Article

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat
[Category] SARS, 치료법,

[키워드] 229E activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against analyzed average BNT162b2 causative agent ChAdOx1 ChAdOx1 nCoV-19 circulating colds common cold Concentration coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccinations cross-neutralization cross-protection determined by Efficiency Endemic Gene Expression HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs Heterologous Huh-7 cells Human human coronavirus incubated individual inhibitory activity MERS MERS-CoV Middle East Middle East respiratory syndrome MOST neutralization neutralize Neutralizing activity NL63 nucleocapsid expression OC43 Preexisting immunity pseudoparticle pseudovirion pseudovirions reporter reporter gene respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination seasonal seasonal coronavirus seasonal coronaviruses seasonal coronaviruses. sera severe acute respiratory syndrome Coronavirus significantly increased Spike proteins these viruses vaccination Viral RNA virus
[DOI] 10.1093/cid/ciac057 PMC 바로가기 [Article Type] Article

Human coronaviruses disassemble processing bodies

Article

Published on 2022-08-232022-11-16
Journal: PLoS Pathogens
[Category] SARS, 유전자 메커니즘,

[키워드] 229E caused cells characteristic common cold CoVs contribute coronavirus Coronavirus infection correlated CoVs cytokine cytoplasmic dysregulated dysregulation expression FIVE fluorescent Granule Human human coronavirus IL-6 immune response impacted infected cell Infection information innate immune response mechanism MERS mRNA transcripts NL63 OC43 processing Proinflammatory cytokine proinflammatory cytokines promote Protein respond responsible ribonucleoprotein RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein screened severe SARS-CoV-2 stability submission the N protein the viral nucleocapsid TNF transcript translation unique viral infection virus
[DOI] 10.1371/journal.ppat.1010724 PMC 바로가기

Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry

액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링

Article

Published on 2022-08-042022-09-11
Journal: Scientific Reports
[Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제,

[키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication
[DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article

SARS-CoV-2 in Atmospheric Particulate Matter: An Experimental Survey in the Province of Venice in Northern Italy

대기 미립자 물질의 SARS-CoV-2: 이탈리아 북부 베니스 지방의 실험적 조사

Article

Published on 2022-08-022022-09-11
Journal: International Journal of Environmental Research an
[Category] SARS, 치료기술,

Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variants

SARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종,

[키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis structural analysis. Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan
[DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article

Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoids

인간 기도 오르가노이드에서 계절성 코로나바이러스의 감염, 열 민감도 및 항바이러스 치료 요약

Article

Published on 2022-07-012022-09-11
Journal: EBioMedicine
[Category] 치료제,

[키워드] 229E Airway organoids Analysis analysis antiviral activity antiviral therapy Antiviral treatment approved conditions Coronavirus infection Coronavirus infections COVID COVID19 development experimental model facilitate favor funding help host response Human human airway Infection infections Infectious virus inhibited interactions Kinetics medication medications Mild molnupiravir Netherland NL63 OC43 occur organization Organoid Pathogenesis phenotype populations Remdesivir replicate Replication Research research and development resulting RNA sequencing robust seasonal seasonal coronavirus seasonal coronaviruses severe complication severe complications Society Support supported temperature tested therapeutic thermal Thermal sensitivity Transcriptome transcriptomic Transmissibility upper respiratory tract viral replication virus replication Virus-host interaction Virus-host interactions virus-host interactions. was performed was tested
[DOI] 10.1016/j.ebiom.2022.104132 PMC 바로가기 [Article Type] Article